effects of different doses of zinc chloride on passive avoidance learning and memory in streptozotocin-induced diabetic adult male rats

Authors

somaieh khosravani no 38, iman 4 street, shaghayegh 20, honarestan shimiayei, farhang shahr, shiraz, iran.

ahmad ali moazedi department of biology,school of science,shahid chamran university,ahvaz

seyed reza fatemi tabatabaee department of statictic,school of matematic,shahid chamran university,ahvaz

seyed reza fatemi

abstract

introduction: zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excretion or lower absorption of zinc in these subjects. therefore, in this study, effects of various doses of zinc chloride on passive avoidance task was investigated in adult male wistar rats without zinc deficiency. methods: male wistar rats (200±20g) with streptozotocin-induced diabetes were used in this study. rats were randomly divided into the groups that received zncl2 (30,50,70,100 mg/kg/day) or the same volume of water (diabetic healthy control group) by oral gavage for two weeks. each rat was then tested by step-down device once daily for 4 days. memory, which was measured by the time that a rat stays on the stone bench, was measured 24h after the last trial (5th day). results: the results showed that the use of zncl2 (30, 50, 70,100 mg/kg) for 2 weeks did not significantly affect passive avoidance learning and memory. conclusion: these results indicate that zncl2 with doses that were administered in this study, does not remarkably affect learning and memory process. this is probably because streptozotocin-induced diabetic rats have zinc deficiency and they require higher doses of zinc supplementation for compensation of zinc loss due to hyperzincuria

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effects of different doses of zinc chloride on passive avoidance learning and memory in streptozotocin-induced diabetic adult male rats

Introduction: Zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. Increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. Some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excret...

full text

Effects of different doses of zinc chloride on passive avoidance learning and memory in streptozotocin-induced diabetic adult male rats

Introduction: Zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. Increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. Some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excretion...

full text

The Effect of Cholesterol and Simvastatin on Passive Avoidance Memory of Streptozotocin-Induced Diabetic Rats

Introduction:Cholesterol has different effects on memory, and diabetes caused adverse effect on cognition. Since there is not enough evidence regarding the effect of cholesterol on memory of diabetic animals, the effects of cholesterol and simvastatin on the passive avoidance memory of diabetic rat were studied. Methods:The study was done on 60 male Wistar rats (180 ± 20g). Diabetes was in...

full text

Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats

Background and Objectives: Alphapinene as one of the most important Components of essential oils, which has antioxidant and anti-cholinesterase activities. Oxidative stress directly affects the function of the brain and causes memory impairment. In this research, the effect of alphapinene on passive avoidance memory and oxidative stress, was investigated in comparison with donepezil.   Methods...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Chronic Rumex Patientia Seed Feeding Improves Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats

A B S T R A C T Introduction: Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Due to anti-diabetic and antioxidant activity of Rumex patientia (RP), this research study was conducted to evaluate the efficacy of chronic Rumex patientia feeding on alleviation of learning and memory disturbance in streptozo...

full text

My Resources

Save resource for easier access later


Journal title:
physiology and pharmacology

جلد ۱۴، شماره ۲، صفحات ۱۴۷-۱۵۴

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023